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Article

Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity.

Nature communications - 4 Jan 2025

Yao Shuyang, Harder Arvid, Darki Fahimeh, Chang Yu-Wei, Li Ang, Nikouei Kasra, Volpe Giovanni, Lundström Johan N, Zeng Jian, Wray Naomi R, Lu Yi, Sullivan Patrick F, Hjerling-Leffler Jens

Abstract excerpt

Identifying cell types and brain regions critical for psychiatric disorders and brain traits is essential for targeted neurobiological research. By integrating genomic insights from genome-wide association studies with a comprehensive single-cell transcriptomic atlas of the adult human brain, we prioritized specific neuronal clusters significantly enriched for the SNP-heritabilities for schizophrenia, bipolar...

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Identifiers

PMID: 39755698
DOI: 10.1038/s41467-024-55611-1
PMCID: PMC11700164

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