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Article

The Role of Cholesterol at the CHOL2 Site and the Dimeric Interface in the Regulation of Serotonin Transporter Function and Dimerization.

Biomolecules - 21 Mar 2026

Yang Jian, Li Chan, Huang Xingyu, Zhang Yuan-Wei

Abstract excerpt

Serotonin transporter (SERT) precisely regulates serotonin (5-HT) signaling in the central nervous system and is a major target of antidepressants for the treatment of major depressive disorder. Despite significant progress in characterizing its structure and transport mechanism, the regulation of SERT function by various modulators remains to be fully understood. In the present study, we focused on two potential...

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PMID: 41897407
DOI: 10.3390/biom16030472
PMCID: PMC13024735

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