Article
Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2009
Quick Matthias, Winther Anne-Marie Lund, Shi Lei, Nissen Poul, Weinstein Harel, Javitch Jonathan A
Abstract excerpt
The first crystal structure of the neurotransmitter/sodium symporter homolog LeuT revealed an occluded binding pocket containing leucine and 2 Na(+); later structures showed tricyclic antidepressants (TCAs) in an extracellular vestibule approximately 11 A above the bound leucine and 2 Na(+). We recently found this region to be a second binding (S2) site and that binding of substrate to this site triggers...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.