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Article

Computational and experimental analysis of the transmembrane domain 4/5 dimerization interface of the serotonin 5-HT(1A) receptor.

Molecular pharmacology - 1 Sept 2012

Gorinski Nataliya, Kowalsman Noga, Renner Ute, Wirth Alexander, Reinartz Michael T, Seifert Roland, Zeug Andre, Ponimaskin Evgeni, Niv Masha Y

Abstract excerpt

Experimental evidence suggests that most members of class A G-protein coupled receptors (GPCRs) can form homomers and heteromers in addition to functioning as single monomers. In particular, serotonin (5-HT) receptors were shown to homodimerize and heterodimerize with other GPCRs, although the details and the physiological role of the oligomerization has not yet been fully elucidated. Here we used computational...

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Identifiers

PMID: 22669805
DOI: 10.1124/mol.112.079137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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