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Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands.

ACS chemical neuroscience - 19 Oct 2016

Andersen Jacob, Ladefoged Lucy Kate, Kristensen Trine N Bjerre, Munro Lachlan, Grouleff Julie, Stuhr-Hansen Nicolai, Kristensen Anders S, Schiøtt Birgit, Strømgaard Kristian

Abstract excerpt

The transporters for the neurotransmitters serotonin and dopamine (SERT and DAT, respectively) are targets for drugs used in the treatment of mental disorders and widely used drugs of abuse. Studies of prokaryotic homologues have advanced our structural understanding of SERT and DAT, but it still remains enigmatic whether the human transporters contain one or two high-affinity substrate binding sites. We have...

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PMID: 27425420
DOI: 10.1021/acschemneuro.6b00164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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