Article
Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters.
Pharmacological research - 1 May 2014
Chiba Peter, Freissmuth Michael, Stockner Thomas
Abstract excerpt
SLC6 family members and ABC transporters represent two extremes: SLC6 transporters are confined to the membrane proper and only expose small segments to the hydrophilic milieu. In ABC transporters the hydrophobic core is connected to a large intracellular (eponymous) ATP binding domain that is comprised of two discontiguous repeats. Accordingly, their folding problem is fundamentally different. This can be gauged...
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