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Article

ATM immunohistochemistry as an effective screening method for POLE variants among endometrial carcinomas lacking mismatch repair deficiency and p53 abnormalities.

The journal of pathology. Clinical research - 1 Mar 2026

Huang Xinyi, Wang Yingmei, Ni Wenjing, Zhong Luyang, Qin Yang, Zeng Shujun, Xu Hong, Qu Yuling, Hu Peizhen, Zhang Jing

Abstract excerpt

The molecular classification of endometrial carcinomas (ECs) is now integrated into clinical practice. However, identification of polymerase-ε (POLE) variants remains reliant on DNA sequencing, which limits broader implementation. Given the strong prognostic value of pathogenic POLE mutations and the established efficacy of immunohistochemistry (IHC) for detecting mismatch repair (MMR) deficiency and p53...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Polymerase II

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Share to High-Throughput Nucleotide Sequencing

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Source

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Identifiers

PMID: 41891942
DOI: 10.1002/2056-4538.70086
PMCID: PMC13093816

Genes

POLE
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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ATM immunohistochemistry as an effective screening method for POLE variants among endometrial carcinomas lacking mismatch repair deficiency and p53 abnormalities.PMID 41891942Read ↗

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