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Article

A Deeper Dive into POLE -Mutated Endometrial Carcinomas : The Contributions and Consequences of Tumor Mutational Burden.

The American journal of surgical pathology - 1 Mar 2026

Vemuri Anusha, Tjota Melissa Y, Wanjari Pankhuri, Fleming Gini F, Wang Peng, Bennett Jennifer A

Abstract excerpt

POLE -mutated endometrial carcinomas ( POLE mut EC) have the most favorable prognosis among all TCGA molecular subgroups. Though the consequent "ultramutated" phenotype is recognized as a trademark feature, hypermutated tumors (10-100 mutations/megabase), as well as those that are histologically low-grade, have been described. Herein, we investigate 19 POLE mut ECs from a single institution to determine whether...

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Source

Identifiers

PMID: 41436846
DOI: 10.1097/PAS.0000000000002503

Genes

POLE
ARID1A
ATRX
BRCA2
NF1
PIK3CA
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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A Deeper Dive into POLE -Mutated Endometrial Carcinomas : The Contributions and Consequences of Tumor Mutational Burden.PMID 41436846Read ↗

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