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Molecular Characterization and Clinical Implications of Endometrial Cancer.

Obstetrics and gynecology - 1 Nov 2025

Secord Angeles Alvarez, Powell Matthew A, McAlpine Jessica

Abstract excerpt

The classification of endometrial cancer (EC) has diverged from traditional histologic features based on microscopic appearance to objective molecular characterization. Molecular characterization of EC is pivotal to inform prognosis and to guide therapeutic recommendations. First described by the Cancer Genome Atlas, molecular profiling was later revised by the Proactive Molecular Risk Classifier for Endometrial...

Topics

Humans
Endometrial Neoplasms
Female
Prognosis
DNA Mismatch Repair
Microsatellite Instability
Biomarkers, Tumor
Mutation
DNA Polymerase II
Immunohistochemistry
Poly-ADP-Ribose Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40966692
DOI: 10.1097/AOG.0000000000006080

Genes

POLE
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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