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Beyond Histology: A Dual-Cohort Genomic Analysis of 2901 Endometrial Carcinomas Reveals Class-Level Mismatch Repair Effects and Refines Molecular Classification.

Genes - 21 May 2026

Sertesen Çamöz Elif, Karabuğa Berkan, Karaçin Cengiz, Terzi Yunus Kasım, Yılmaz Çelik Zerrin

Abstract excerpt

Background: Endometrial carcinoma (EC) is now classified primarily by molecular subtype-POLE-ultramutated, mismatch repair-deficient (dMMR), TP53-mutant/copy-number-high (CNH), and "no specific molecular profile" (NSMP)-a framework that has reshaped prognostic counseling and adjuvant therapy decisions. Yet several practically important questions remain insufficiently addressed in real-world cohorts: whether all...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42195047
DOI: 10.3390/genes17050591
PMCID: PMC13205493

Genes

POLE
TP53
IMPACT
MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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