DNA affects the phenotype of fuel-dependent coacervate droplets.

Abstract excerpt

Synthetic cells emulate fundamental biological behaviors, like growth, metabolism, and mobility, but have lacked genotype-driven selection, which is essential for Darwinian evolution. Here, we introduce libraries of short DNA sequences as genotypes into fuel-dependent peptide-RNA-based coacervate droplets, serving as synthetic cells. By sequencing, we identify sequences that partition in the droplets, revealing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA
• Share to Genotype
• Share to Peptides