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Article

Combinatorial Optimization of Protein Systems in Synthetic Cells.

ACS synthetic biology - 21 Aug 2026

van den Brink Marijn, Claassens Nico J, Danelon Christophe

Abstract excerpt

In vitro reconstitution of protein systems─e.g., metabolic pathways, genetic circuits, or biosensors─often requires optimization to enhance their activity. Combinatorial DNA libraries that simultaneously target multiple genes allow for a holistic optimization strategy by studying the interplay between the systems' components, which may reveal DNA variants that would be hidden when testing each element in...

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Identifiers

PMID: 42632026
DOI: 10.1021/acssynbio.6c00166
PMCID: PMC13505333

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