Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spontaneous mutations to delamanid and pretomanid resistance in Mycobacterium tuberculosis: SNPs confer high-level resistance.

International journal of antimicrobial agents - 1 Jun 2026

Zhang Qian, Xu Peng, Zhang Xuecong, Pi Rui, Chen Yiwang, Takiff Howard, Gao Qian

Abstract excerpt

OBJECTIVES: Multidrug-resistant tuberculosis (MDR-TB) remains a major global health threat. Delamanid (DLM) and pretomanid (PMD) are core drugs in new multidrug-resistant tuberculosis regimens, but the spectrum of their resistance mutations is poorly defined. METHODS: To investigate these mutations, five parallel in vitro experiments selected for resistance to DLM or PMD. Mycobacterium tuberculosis H37Rv cultures...

Topics

Mycobacterium tuberculosis
Microbial Sensitivity Tests
Polymorphism, Single Nucleotide
Antitubercular Agents
Nitroimidazoles
Whole Genome Sequencing
Mutation
Humans
Oxazoles
Drug Resistance, Multiple, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tuberculosis, Multidrug-Resistant

Source

Identifiers

PMID: 41881163
DOI: 10.1016/j.ijantimicag.2026.107789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41881163-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spontaneous mutations to delamanid and pretomanid resistance in Mycobacterium tuberculosis: SNPs confer high-level resistance.PMID 41881163Read ↗

Spontaneous Mutational Patterns and Novel Mutations for Delamanid Resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Investigation of genomic mutations and their association with phenotypic resistance to new and repurposed drugs in Mycobacterium tuberculosis complex clinical isolates.Semantic proximity Read ↗

Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.Semantic proximity Read ↗

Delamanid Resistance: Update and Clinical ManagementSemantic proximity Read ↗

Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid.Semantic proximity Read ↗

Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients.Semantic proximity Read ↗

Widespread loss-of-function mutations implicating preexisting resistance to new or repurposed anti-tuberculosis drugsSemantic proximity Read ↗

Delamanid and bedaquiline resistance patterns in Mycobacterium tuberculosis in Iran: A cross-sectional analysisSemantic proximity Read ↗

Characterization of genomic variants associated with resistance to bedaquiline and delamanid in naïve <i>Mycobacterium tuberculosis</i> clinical strainsSemantic proximity Read ↗

Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical StrainsSemantic proximity Read ↗

Natural Polymorphisms in <i>Mycobacterium tuberculosis</i> Conferring Resistance to Delamanid in Drug-naïve PatientsSemantic proximity Read ↗

Evolution of Mycobacterium tuberculosis drug resistance in the genomic era.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.