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Natural Polymorphisms in <i>Mycobacterium tuberculosis</i> Conferring Resistance to Delamanid in Drug-naïve Patients

2020-08-11

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the genes of the F 420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC , and fbiD , of Mycobacterium tuberculosis ( Mtb ) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For ten strains with mutatio...

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Literature Corpus work
0abb4839-2407-5653-ab3b-0f9c5be61d37
DOI
10.1101/2020.08.07.20167130
Open publication

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Natural Polymorphisms in <i>Mycobacterium tuberculosis</i> Conferring Resistance to Delamanid in Drug-naïve PatientsDOI 10.1101/2020.08.07.20167130
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