Article
Investigation of genomic mutations and their association with phenotypic resistance to new and repurposed drugs in Mycobacterium tuberculosis complex clinical isolates.
The Journal of antimicrobial chemotherapy - 6 Nov 2023
Mok Simone, Roycroft Emma, Flanagan Peter R, Wagener Johannes, Fitzgibbon Margaret M
Abstract excerpt
BACKGROUND: WGS has the potential to detect resistance-associated mutations and guide treatment of MDR TB. However, the knowledge base to confidently interpret mutations associated with the new and repurposed drugs is sparse, and phenotypic drug susceptibility testing is required to detect resist...
Topics
- Humans
- Antitubercular Agents
- Mycobacterium tuberculosis
- Clofazimine
- Tuberculosis, Multidrug-Resistant
- Linezolid
- Microbial Sensitivity Tests
- Diarylquinolines
- Mutation
- Genomics