Article
Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients.
Antimicrobial agents and chemotherapy - 20 Oct 2020
Reichmuth Martina L, Hömke Rico, Zürcher Kathrin, Sander Peter, Avihingsanon Anchalee, Collantes Jimena, Loiseau Chloé, Borrell Sonia, Reinhard Miriam, Wilkinson Robert J, Yotebieng Marcel, Fenner Lukas, Böttger Erik C, Gagneux Sebastien, Egger Matthias, Keller Peter M
Abstract excerpt
Mutations in the genes of the F420 signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For 10 strains with mutations, we determined...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.