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Article

Spontaneous Mutational Patterns and Novel Mutations for Delamanid Resistance in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 20 Dec 2022

Liu Yuanyuan, Shi Jin, Li Lu, Wu Tuoya, Chu Ping, Pang Yu, Guo Yongli, Gao Mengqiu, Lu Jie

Abstract excerpt

Delamanid (DLM) and pretomanid (PTM) are recent additions to the anti-tuberculosis (TB) drug armamentarium, and they offer more effective options for drug-resistant TB treatment. In particular, DLM is included in Group C, which is recommended for use in longer multidrug-resistant (MDR)-TB regimens. Previous studies have shown that resistance to DLM/PTM is caused by mutations in the ddn, fgd1, fbiA, fbiB, fbiC,...

Topics

Antitubercular Agents
Drug Resistance, Multiple, Bacterial
Microbial Sensitivity Tests
Mutation
Mycobacterium tuberculosis
Prodrugs

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36448833
DOI: 10.1128/aac.00531-22
PMCID: PMC9765178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-36448833-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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