Article
Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA).
JAMA neurology - 1 Mar 2014
Vardarajan Badri N, Faber Kelley M, Bird Thomas D, Bennett David A, Rosenberg Roger, Boeve Bradley F, Graff-Radford Neill R, Goate Alison M, Farlow Martin, Sweet Robert A, Lantigua Rafael, Medrano Martin Z, Ottman Ruth, Schaid Daniel J, Foroud Tatiana M, Mayeux Richard
Abstract excerpt
IMPORTANCE: Late-onset Alzheimer disease (LOAD), defined as onset of symptoms after age 65 years, is the most common form of dementia. Few reports investigate incidence rates in large family-based studies in which the participants were selected for family history of LOAD. OBJECTIVE: To determine the incidence rates of dementia and LOAD in unaffected members in the National Institute on Aging Genetics Initiative...
Topics
- Age Factors
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoprotein E4
- Dominican Republic
- Female