Article
Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.
Neurobiology of disease - 1 Jan 1996
Xu P T, Schmechel D, Rothrock-Christian T, Burkhart D S, Qiu H L, Popko B, Sullivan P, Maeda N, Saunders A M, Roses A D, Gilbert J R
Abstract excerpt
Apolipoprotein E (apoE) and its three major alleles (APOE2, E3, and E4) have been implicated in Alzheimer's disease and other neurological disorders. Little is known of the role apoE plays in normal brain function and pathology. To create a model to study apoE in brain, we have generated APOE tra...
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