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Adjuvant aspirin for colorectal cancer with PIK3CA-mutated and COX-2 overexpressed tumours: the ASCOLT translational research study and meta-analysis.

EBioMedicine - 1 Aug 2026

Segelov Eva, Li Shan, Li Isabel, Mouradov Dmitri, Yip Sonia, Day Daphne, Jeffery Mark, Zielinski Rob, Nott Louise, Sun Yuntian, Christie Michael, Ho Gwo Fuang, Chao Tsu-Yi, Rahman Nabilah, Foo Estelle, Chia John, Gebski Val, Toh Han Chong, Sieber Oliver M, Simes John

Abstract excerpt

BACKGROUND: ASCOLT compared adjuvant aspirin versus (vs) placebo in 1587 patients with colorectal cancer (CRC) and reported no significant improvement in disease-free survival (DFS). Subsequently, two randomised controlled trials (RCTs) reported benefit of adjuvant aspirin in CRC patients with somatic PI3K-related mutations. METHODS: The ASCOLT Translational Research (TR) study was a preplanned subgroup analysis...

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Aged
Aspirin
Chemotherapy, Adjuvant
Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Colorectal Neoplasms

Cyclooxygenase 2

Translational Research, Biomedical

Treatment Outcome

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Open in PubMed Open full text

Identifiers

PMID: 42475879
DOI: 10.1016/j.ebiom.2026.106389
PMCID: PMC13393707

Genes

PIK3CA
PTEN
PTGS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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