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Article

Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo.

Scientific reports - 16 Dec 2019

Zhao Yiqing, Zhao Xuan, Chen Vanessa, Feng Ying, Wang Lan, Croniger Colleen, Conlon Ronald A, Markowitz Sanford, Fearon Eric, Puchowicz Michelle, Brunengraber Henri, Hao Yujun, Wang Zhenghe

Abstract excerpt

Cancer cells in culture rely on glutamine as an anaplerotic substrate to replenish tricarboxylic acid (TCA) cycle intermediates that have been consumed. but it is uncertain whether cancers in vivo depend on glutamine for anaplerosis. Here, following in vivo infusions of [13C5]-glutamine in mice bearing subcutaneous colon cancer xenografts, we showed substantial amounts of infused [13C5]-glutamine enters the TCA...

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Identifiers

PMID: 31844152
DOI: 10.1038/s41598-019-55718-2
PMCID: PMC6915720

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