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Article

Non-Invasive Glutamine PET Reflects Pharmacological Inhibition of BRAFV600E In Vivo.

Molecular imaging and biology - 1 Jun 2017

Schulte Michael L, Hight Matthew R, Ayers Gregory D, Liu Qi, Shyr Yu, Washington M Kay, Manning H Charles

Abstract excerpt

PURPOSE: This study aimed to study whether cancer cells possess distinguishing metabolic features compared with surrounding normal cells, such as increased glutamine uptake. Given this, quantitative measures of glutamine uptake may reflect critical processes in oncology. Approximately, 10 % of patients with colorectal cancer (CRC) express BRAF V600E , which may be actionable with selective BRAF inhibitors or in...

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Source

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Identifiers

PMID: 27770401
DOI: 10.1007/s11307-016-1008-z
PMCID: PMC6476310

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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