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WormTagDB: a systematic survey of endogenously tagged proteins in Caenorhabditis elegans and roadmap toward the tagged proteome.

G3 (Bethesda, Md.) - 3 Jun 2026

Leyhr Jake, Chi Qiuyi, Zeng Lin, Li Xuejia, Cao Beibei, Shen En-Zhi, Zou Wei, Sherwood David R

Abstract excerpt

Endogenous protein tagging in Caenorhabditis elegans enables the direct visualization and manipulation of proteins in vivo, providing native readouts of expression, localization, and dynamics. No coordinated effort currently exists to comprehensively tag proteins on a large scale, resulting in patchy coverage that limits proteome-wide analyses. We systematically reviewed 2,500 primary research articles,...

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PMID: 41873681
DOI: 10.1093/g3journal/jkag068
PMCID: PMC13232489

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