Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2022

Angelini Aude, Ortiz-Urbina Jesus, Trial JoAnn, Reddy Anilkumar K, Malovannaya Anna, Jain Antrix, Entman Mark L, Taffet George E, Cieslik Katarzyna A

Abstract excerpt

The incidence of diastolic dysfunction increases with age in both humans and mice. This is characterized by increased passive stiffness and slower relaxation of the left ventricle. The stiffness arises at least partially from progressively increased interstitial collagen deposition because of highly secretory fibroblasts. In the past, we demonstrated that AMPK activation via the drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Aminoimidazole Carboxamide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to AMP-Activated Protein Kinases

Share to Cardiomyopathies

Share to Collagen

Share to Fibrosis

Share to Zinc Finger Protein GLI1

Source

Open in PubMed Open full text

Identifiers

PMID: 35714177
DOI: 10.1152/ajpheart.00078.2022
PMCID: PMC9273262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis.PMID 35714177Read ↗

Age and gender effects on echocardiographic and histopathological cardiac phenotypes in healthy adult mice.Semantic proximity Read ↗

Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice.Semantic proximity Read ↗

Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagySemantic proximity Read ↗

Control of cardiac remodelling during ageing and disease by epigenetic modifications and modifiersSemantic proximity Read ↗

Changes in cardiac resident fibroblast physiology and phenotype in aging.Semantic proximity Read ↗

Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure.Semantic proximity Read ↗

Sex-Specific Characterization of a Novel Osteoarthritis-Induced Heart Failure Model in MiceSemantic proximity Read ↗

Myofibroblast-mediated mechanisms of pathological remodelling of the heart.Semantic proximity Read ↗

PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in miceSemantic proximity Read ↗

p38β/MAPK11 Deficiency Exacerbates Cardiac Structural and Electrophysiological Remodeling and Contributes to Immune Dysregulation in the Aging HeartSemantic proximity Read ↗

Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working Group 'Myocardial Function' of the ESC.Semantic proximity Read ↗

Electrophysiological and Structural Remodeling of the Atria in a Mouse Model of Troponin-I Mutation Linked Hypertrophic Cardiomyopathy: Implications for Atrial Fibrillation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.