Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Female ClockΔ19/Δ19 mice are protected from the development of age-dependent cardiomyopathy.

Cardiovascular research - 1 Feb 2018

Alibhai Faisal J, Reitz Cristine J, Peppler Willem T, Basu Poulami, Sheppard Paul, Choleris Elena, Bakovic Marica, Martino Tami A

Abstract excerpt

Aims: Circadian rhythms are important for healthy cardiovascular physiology and they are regulated by the molecular circadian mechanism. Previously, we showed that disruption of the circadian mechanism factor CLOCK in male ClockΔ19/Δ19 mice led to development of age-dependent cardiomyopathy. Here, we investigate the role of biological sex in protecting against heart disease in aging female ClockΔ19/Δ19 mice....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiolipins
Share to Cardiomyopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circadian Rhythm

Share to CLOCK Proteins

Share to Hemodynamics

Share to Ovariectomy

Share to Ventricular Function, Left

Source

Identifiers

PMID: 28927226
DOI: 10.1093/cvr/cvx185

Genes

CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Female ClockΔ19/Δ19 mice are protected from the development of age-dependent cardiomyopathy.PMID 28927226Read ↗

Evaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and 640/750 days of age.Semantic proximity Read ↗

Circadian mutant mice with obesity and metabolic syndrome are resilient to cardiovascular disease.Semantic proximity Read ↗

The role of sex in cardiac function and diseaseThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.Semantic proximity Read ↗

Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice.Semantic proximity Read ↗

PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in miceSemantic proximity Read ↗

Age and gender effects on echocardiographic and histopathological cardiac phenotypes in healthy adult mice.Semantic proximity Read ↗

Genes of the fatty acid oxidation pathway are upregulated in female as compared to male cardiomyocytesSemantic proximity Read ↗

The Cardiomyocyte Circadian ClockSemantic proximity Read ↗

Cardiac Sex Differences are Established Prior to Gonad FormationSemantic proximity Read ↗

Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different AgesSemantic proximity Read ↗

Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implicationsSemantic proximity Read ↗

Proteogenomic characterization of age and sex interactions in cardiac gene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.