Homologous recombination mutants cause differing lethality between h- and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin.

Abstract excerpt

Homologous recombination (HR) is generally considered dispensable in yeast and vertebrates, yet mounting evidence indicates that its essentiality depends on cellular context. Here, we dissect the basis of this context dependency in Schizosaccharomyces pombe. In the homothallic h90 strain, regarded as wild type, mating-type switching (MTS) occurs every other cell division and requires HR to repair programmed...

Topics

• Homologous Recombination
• Mutation
• Schizosaccharomyces
• Genes, Mating Type, Fungal
• Microbial Viability
• Genes, Suppressor