Article

A single Ho-induced double-strand break at the <i>MAT</i> locus is lethal in <i>Candida glabrata</i>

2020-01-27

Abstract excerpt

Mating-type switching is a complex mechanism that promotes sexual reproduction in Ascomycotina. In the model species Saccharomyces cerevisiae , mating-type switching is initiated by the Ho endonuclease that performs a site-specific double-strand break (DSB) at MAT , repaired by homologous recombination (HR) using one of the two silent mating type cassettes, HMLalpha and HMRa . The reasons why all the elements...

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Literature Corpus work: 09dd932d-b00e-523b-ba35-33a7ebca6d02
DOI: 10.1101/2020.01.27.920876

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