Article
Different mating-type-regulated genes affect the DNA repair defects of Saccharomyces RAD51, RAD52 and RAD55 mutants.
Genetics - 1 Sept 2006
Valencia-Burton Maria, Oki Masaya, Johnson Jean, Seier Tracey A, Kamakaka Rohinton, Haber James E
Abstract excerpt
Saccharomyces cerevisiae cells expressing both a- and alpha-mating-type (MAT) genes (termed mating-type heterozygosity) exhibit higher rates of spontaneous recombination and greater radiation resistance than cells expressing only MATa or MATalpha. MAT heterozygosity suppresses recombination defects of four mutations involved in homologous recombination: complete deletions of RAD55 or RAD57, an ATPase-defective...
Topics
- Chromatin
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Flavoproteins
- Gene Deletion
- Genes, Fungal
- Genes, Mating Type, Fungal
- Haploidy
- Histone Deacetylases
- Mutation
- Peptidylprolyl Isomerase
- Protein Structure, Tertiary