Large impact of genetic data processing steps on stability and reproducibility of set-based analyses in genome-wide association studies.

Abstract excerpt

Genome-wide association studies (GWAS) are a foundational tool in human genetics research, however, challenges in stability and reproducibility of GWAS results are often noted. The main goals of this work are to describe, analyze, and provide tools for solving such reproducibility challenges in a popular component of GWAS literature: set-based (a) hypothesis testing and (b) effect size estimation studies. Common...

Topics

• Genome-Wide Association Study
• Humans
• Reproducibility of Results
• Models, Genetic
• Genetic Risk Score
• Models, Statistical