Article
The statistical properties of gene-set analysis.
Nature reviews. Genetics - 12 Apr 2016
de Leeuw Christiaan A, Neale Benjamin M, Heskes Tom, Posthuma Danielle
Abstract excerpt
The rapid increase in loci discovered in genome-wide association studies has created a need to understand the biological implications of these results. Gene-set analysis provides a means of gaining such understanding, but the statistical properties of gene-set analysis are not well understood, which compromises our ability to interpret its results. In this Analysis article, we provide an extensive statistical...
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