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Article

Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies.

Genetic epidemiology - 1 Feb 2010

Yoo Yun J, Bull Shelley B, Paterson Andrew D, Waggott Daryl, Sun Lei

Abstract excerpt

A central issue in genome-wide association (GWA) studies is assessing statistical significance while adjusting for multiple hypothesis testing. An equally important question is the statistical efficiency of the GWA design as compared to the traditional sequential approach in which genome-wide linkage analysis is followed by region-wise association mapping. Nevertheless, GWA is becoming more popular due in part to...

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PMID: 19626703
DOI: 10.1002/gepi.20438
PMCID: PMC2811772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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