Article
Gene set analysis of genome-wide association studies: methodological issues and perspectives.
Genomics - 1 Jul 2011
Wang Lily, Jia Peilin, Wolfinger Russell D, Chen Xi, Zhao Zhongming
Abstract excerpt
Recent studies have demonstrated that gene set analysis, which tests disease association with genetic variants in a group of functionally related genes, is a promising approach for analyzing and interpreting genome-wide association studies (GWAS) data. These approaches aim to increase power by combining association signals from multiple genes in the same gene set. In addition, gene set analysis can also shed more...
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