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Article

Defining the power limits of genome-wide association scan meta-analyses.

Genetic epidemiology - 1 Dec 2011

Chapman Kay, Ferreira Teresa, Morris Andrew, Asimit Jennifer, Zeggini Eleftheria

Abstract excerpt

Large-scale meta-analyses of genome-wide association scans (GWAS) have been successful in discovering common risk variants with modest and small effects. The detection of lower frequency signals will undoubtedly require concerted efforts of at least similar scale. We investigate the sample size-dictated power limits of GWAS meta-analyses, in the presence and absence of modest levels of heterogeneity and across a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21922540
DOI: 10.1002/gepi.20627
PMCID: PMC3428938

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