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Article

EraSOR: a software tool to eliminate inflation caused by sample overlap in polygenic score analyses.

GigaScience - 28 Dec 2022

Choi Shing Wan, Mak Timothy Shin Heng, Hoggart Clive J, O'Reilly Paul F

Abstract excerpt

BACKGROUND: Polygenic risk score (PRS) analyses are now routinely applied across biomedical research. However, as PRS studies grow in size, there is an increased risk of sample overlap between the genome-wide association study (GWAS) from which the PRS is derived and the "target sample," in which PRSs are computed and hypotheses are tested. Despite the wide recognition of the sample overlap problem, its potential...

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PMID: 37326441
DOI: 10.1093/gigascience/giad043
PMCID: PMC10273836

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