Article
Quality control procedures for genome-wide association studies.
Current protocols in human genetics - 1 Jan 2011
Turner Stephen, Armstrong Loren L, Bradford Yuki, Carlson Christopher S, Crawford Dana C, Crenshaw Andrew T, de Andrade Mariza, Doheny Kimberly F, Haines Jonathan L, Hayes Geoffrey, Jarvik Gail, Jiang Lan, Kullo Iftikhar J, Li Rongling, Ling Hua, Manolio Teri A, Matsumoto Martha, McCarty Catherine A, McDavid Andrew N, Mirel Daniel B, Paschall Justin E, Pugh Elizabeth W, Rasmussen Luke V, Wilke Russell A, Zuvich Rebecca L, Ritchie Marylyn D
Abstract excerpt
Genome-wide association studies (GWAS) are being conducted at an unprecedented rate in population-based cohorts and have increased our understanding of the pathophysiology of complex disease. Regardless of context, the practical utility of this information will ultimately depend upon the quality of the original data. Quality control (QC) procedures for GWAS are computationally intensive, operationally...
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