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Article

Biochemical characterization of IMP-30, a metallo-β-lactamase with enhanced activity toward ceftazidime.

Antimicrobial agents and chemotherapy - 1 Oct 2013

Pegg Kevin M, Liu Eleanor M, Lacuran Alecander E, Oelschlaeger Peter

Abstract excerpt

IMP-type enzymes constitute a clinically important family of metallo-β-lactamases that has grown dramatically in the past decade to its current 45 known members. Here, we report the biochemical characterization of IMP-30 in comparison to IMP-1, from which it deviates by a single E59K mutation. Kinetics, MIC assays, docking, and molecular dynamics simulations support a scenario in which Lys59 interacts with the...

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Identifiers

PMID: 23836186
DOI: 10.1128/AAC.02341-12
PMCID: PMC3811441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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