Article
Understanding the determinants of substrate specificity in IMP family metallo-β-lactamases: the importance of residue 262.
Protein science : a publication of the Protein Society - 1 Oct 2014
Pegg Kevin M, Liu Eleanor M, George Alex C, LaCuran Alecander E, Bethel Christopher R, Bonomo Robert A, Oelschlaeger Peter
Abstract excerpt
In Gram-negative bacteria, resistance to β-lactam antibacterials is largely due to β-lactamases and is a growing public health threat. One of the most concerning β-lactamases to evolve in bacteria are the Class B enzymes, the metallo-β-lactamases (MBLs). To date, penams and cephems resistant to hydrolysis by MBLs have not yet been found. As a result of this broad substrate specificity, a better understanding of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.