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Article

Elucidating the Role of Residue 67 in IMP-Type Metallo-β-Lactamase Evolution.

Antimicrobial agents and chemotherapy - 1 Dec 2015

LaCuran Alecander E, Pegg Kevin M, Liu Eleanor M, Bethel Christopher R, Ai Ni, Welsh William J, Bonomo Robert A, Oelschlaeger Peter

Abstract excerpt

Antibiotic resistance in bacteria is ever changing and adapting, as once-novel β-lactam antibiotics are losing their efficacy, primarily due to the production of β-lactamases. Metallo-β-lactamases (MBLs) efficiently inactivate a broad range of β-lactam antibiotics, including carbapenems, and are often coexpressed with other antibacterial resistance factors. The rapid dissemination of MBLs and lack of novel...

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Identifiers

PMID: 26369960
DOI: 10.1128/AAC.01651-15
PMCID: PMC4649200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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