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Article

The BDNF val66met polymorphism is associated with decreased use of landmarks and decreased fMRI activity in the hippocampus during virtual navigation.

The European journal of neuroscience - 1 Oct 2021

West Greg L, Konishi Kyoko, MacDonald Kathleen, Ni Anjie, Joober Ridha, Bohbot Veronique D

Abstract excerpt

People can navigate in a new environment using multiple strategies dependent on different memory systems. A series of studies have dissociated between hippocampus-dependent 'spatial' navigation and habit-based 'response' learning mediated by the caudate nucleus. The val66met polymorphism of the brain-derived neurotrophic factor (BDNF) gene leads to decreased secretion of BDNF in the brain, including the...

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PMID: 34467592
DOI: 10.1111/ejn.15431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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