Current evidence on the effect of highly effective CFTR modulation on interleukin-8 in cystic fibrosis.

Abstract excerpt

INTRODUCTION: Cystic fibrosis (CF) is a genetically inherited disease, with mortality and morbidity associated with respiratory disease. The inflammatory response in CF is characterized by excessive neutrophil influx to the airways, mainly due to the increased local production and retention of interleukin-8 (IL-8), a potent neutrophil chemoattractant. AREAS COVERED: We discuss how the chemokine IL-8 dominates the...

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