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Article

The Cystic Fibrosis Neutrophil: A Specialized Yet Potentially Defective Cell

10 Feb 2011

Abstract excerpt

Cystic fibrosis (CF) is one of the commonest genetically inherited diseases in the world. It is characterized by recurrent respiratory tract infections eventually leading to respiratory failure. One of the hallmarks of this disease is a persistent and predominantly neutrophil driven inflammation. Neutrophils provide the first line of defence by killing and digesting phagocytosed bacteria and fungi, yet despite...

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PMID: 21311988
DOI: 10.1007/s00005-011-0113-6

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