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Article

Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.

Biochimica et biophysica acta. Molecular cell research - 1 Feb 2017

Aras Siddhesh, Arrabi Hassan, Purandare Neeraja, Hüttemann Maik, Kamholz John, Züchner Stephan, Grossman Lawrence I

Abstract excerpt

We previously showed that MNRR1 (Mitochondrial Nuclear Retrograde Regulator 1, also CHCHD2) functions in two subcellular compartments, displaying a different function in each. In the mitochondria it is a stress regulator of respiration that binds to cytochrome c oxidase (COX) whereas in the nucleus it is a transactivator of COX4I2 and other hypoxia-stimulated genes. We now show that binding of MNRR1 to COX is...

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Identifiers

PMID: 27913209
DOI: 10.1016/j.bbamcr.2016.11.029

Genes

CHCHD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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