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The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity

3 Jul 2024

Abstract excerpt

Nuclear receptor coactivator 4 (NCOA4) has recently been recognized as a selective cargo receptor of ferritinophagy participating in ferroptosis. However, NCOA4 is also a coactivator that modulates the transcriptional activity of many vital nuclear receptors. Recent novel studies have documented the role of NCOA4 in healthy and pathogenic conditions via its modulation of iron- and non-iron-dependent metabolic...

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PMID: 38961066
DOI: 10.1038/s41420-024-02075-3

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