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Nuclear Functions of TOR: Impact on Transcription and the Epigenome

10 Jun 2020

Abstract excerpt

The target of rapamycin (TOR) protein kinase is at the core of growth factor- and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stability. TOR affects nuclear functions indirectly through its activity in the cytoplasm, but also directly through...

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PMID: 32532005
DOI: 10.3390/genes11060641

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