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Article

Identification of novel nuclear targets of human thioredoxin 1.

Molecular & cellular proteomics : MCP - 1 Dec 2014

Wu Changgong, Jain Mohit Raja, Li Qing, Oka Shin-Ichi, Li Wenge, Kong Ah-Ng Tony, Nagarajan Narayani, Sadoshima Junichi, Simmons William J, Li Hong

Abstract excerpt

The dysregulation of protein oxidative post-translational modifications has been implicated in stress-related diseases. Trx1 is a key reductase that reduces specific disulfide bonds and other cysteine post-translational modifications. Although commonly in the cytoplasm, Trx1 can also modulate transcription in the nucleus. However, few Trx1 nuclear targets have been identified because of the low Trx1 abundance in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25231459
DOI: 10.1074/mcp.M114.040931
PMCID: PMC4256501

Genes

PSIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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