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Article

Sex-stratified genetic regulators of cytokine production in the Dutch and Tanzanian populations.

HGG advances - 9 Apr 2026

Amour Caroline, Cetatean Raul, Ponce Isis Ricano, Keur Nick, Temba Godfrey S, Kullaya Vesla I, Mmbaga Blandina T, Kavishe Reginald, Joosten Leo A B, Netea Mihai G, de Mast Quirijn, Boahen Collins K, Kumar Vinod

Abstract excerpt

Differences in immune responses are observed between males and females, influenced by genetic, hormonal, and environmental factors. The sex-specific genetic effects on cytokine production, however, remain underexplored. This study aimed to identify sex-specific quantitative trait loci (QTLs) affecting cytokine production in response to diverse infectious antigens. We performed sex-stratified cytokine QTL (cQTLs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 41858114
DOI: 10.1016/j.xhgg.2026.100593
PMCID: PMC13071459

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