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Article

The impact of sex on the immune system explored at the single-cell level.

American journal of human genetics - 7 May 2026

Yazar Seyhan, Alquicira-Hernandez Jose, Wing Kristof, Senabouth Anne, Andersen Stacey, Fairfax Kirsten A, Hewitt Alex W, Powell Joseph E, Ballouz Sara

Abstract excerpt

Sex has a key role in disease susceptibility (in particular, autoimmunity). Sex differences in the immune system originate from genes and their interactions with both intrinsic and extrinsic factors. However, the cellular-level factors influencing sexual dimorphism are not fully understood. We thus examined immune sex differences at single-cell resolution to dissect the genetic impacts. Female-biased...

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Share to Immune System
Share to Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

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Source

Identifiers

PMID: 42102734
DOI: 10.1016/j.ajhg.2026.04.003

Genes

FCGR3A
ITGB2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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