Article
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2018
Piasecka Barbara, Duffy Darragh, Urrutia Alejandra, Quach Hélène, Patin Etienne, Posseme Céline, Bergstedt Jacob, Charbit Bruno, Rouilly Vincent, MacPherson Cameron R, Hasan Milena, Albaud Benoit, Gentien David, Fellay Jacques, Albert Matthew L, Quintana-Murci Lluis
Abstract excerpt
The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and searched for the determinants of immune response variation. We found that age and sex affected the transcriptional response of most...
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