Article
A metastable rRNA junction essential for bacterial 30S biogenesis.
Nucleic acids research - 1 Jun 2018
Sharma Indra Mani, Rappé Mollie C, Addepalli Balasubrahmanyam, Grabow Wade W, Zhuang Zhuoyun, Abeysirigunawardena Sanjaya C, Limbach Patrick A, Jaeger Luc, Woodson Sarah A
Abstract excerpt
Tertiary sequence motifs encode interactions between RNA helices that create the three-dimensional structures of ribosomal subunits. A Right Angle motif at the junction between 16S helices 5 and 6 (J5/6) is universally conserved amongst small subunit rRNAs and forms a stable right angle in minimal RNAs. J5/6 does not form a right angle in the mature ribosome, suggesting that this motif encodes a metastable...
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