Article
Characterization of 16S rRNA mutations that decrease the fidelity of translation initiation.
RNA (New York, N.Y.) - 1 Dec 2007
Qin Daoming, Abdi Nimo M, Fredrick Kurt
Abstract excerpt
In bacteria, initiation of translation is kinetically controlled by factors IF1, IF2, and IF3, which work in conjunction with the 30S subunit to ensure accurate selection of the initiator tRNA (fMet-tRNA(fMet)) and the start codon. Here, we show that mutations G1338A and A790G of 16S rRNA decrease initiation fidelity in vivo and do so in distinct ways. Mutation G1338A increases the affinity of tRNA(fMet) for the...
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